Prommune is a research and development company that has created a unique and patented means to safely and effectively awaken the body’s own natural immune defenses without inflammatory side-effects. Such immune activation is possible through the use of novel immune stimulatory peptides, which are derived from a naturally-occurring protein component of the immune system. The use of these host-derived immune stimulatory peptides provides a broad therapeutic platform enabling the treatment of normal and antibiotic-resistant infections and the rapid generation a huge variety of new vaccines for human and veterinary medicine.
Protective EP67-based vaccines made to:
EP67-induced host-directed immunotherapy against:
Because of the ability of EP67 to selectively engage/activate antigen presenting cells, EP67 can be used as a component in the design of vaccines. A vaccine is rapidly made by the straightforward conjugation of EP67 to the surface of a protein antigen. The EP67 moiety targets the protein antigen to and activates the antigen presenting cells such that the antigen is now effectively and properly presented to the lymphocyte population of immune cells, which generate the long-term memory immune responses against re-exposure to the pathogen that bears the protein against which the EP67-based vaccine was made.
Prommune’s lead immune simulatory peptide, EP67, selectively engages and activates antigen presenting cells (monocytes, macrophages, dendritic cells) to induce the cellular and molecular elements associated with innate immunity – the body’s first line of immune defense against infection. Once activated by EP67, these antigen presenting cells are primed to take up infective pathogens (bacteria, viruses, fungi) and destroy them via natural cellular mechanisms. Thus, EP67 can be used to awaken and direct the body’s own innate immune responses against infective pathogens – Host-Directed Immune Therapy (HDIT). Importantly, the EP67-activated cellular processes for HDIT make no distinction between normal or antibiotic-resistant pathogens. Thus, EP67-mediated HDIT can be used to fight normal as well as antibiotic-resistant infections and could be used as a complement to traditional antibiotics to deliver a powerful dual therapeutic assault on troublesome infections.
A unique ability to safely and effectively activate the body’s own natural immune responses.
A platform technology allowing for the development of a huge variety of vaccines, host-directed immunotherapy against normal and antibiotic-resistant infections, and enhancing the wound healing process.
Therapies being developed that utilize this platform technology in human and veterinary medicine.